CaBP1 Regulates Both Ca and Ba currents through Ca(v)1.2 (L-type) Calcium Channels
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چکیده
منابع مشابه
Inactivation of Gating Currents of L-Type Calcium Channels
In studies of gating currents of rabbit cardiac Ca channels expressed as alpha 1C/beta 2a or alpha 1C/beta 2a/alpha 2 delta subunit combinations in tsA201 cells, we found that long-lasting depolarization shifted the distribution of mobile charge to very negative potentials. The phenomenon has been termed charge interconversion in native skeletal muscle (Brum, G., and E. Ríos. 1987. J. Physiol. ...
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Tully, Keith and Steven N. Treistman. Distinct intracellular calcium profiles following influx through Nversus L-type calcium channels: role of Ca -induced Ca release. J Neurophysiol 92: 135–143, 2004; 10.1152/jn.01004.2003. Selective activation of neuronal functions by Ca is determined by the kinetic profile of the intracellular calcium ([Ca ]i) signal in addition to its amplitude. Concurrent ...
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Duchenne muscular dystrophy (DMD), induced by mutations in the gene encoding for the cytoskeletal protein dystrophin, is an inherited disease characterized by progressive muscle weakness. Besides the relatively well characterized skeletal muscle degenerative processes, DMD is also associated with cardiac complications. These include cardiomyopathy development and cardiac arrhythmias. The curren...
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Ca2+ currents in neurons and muscle cells have been classified as being one of 5 types of which four, L, N, P/Q and R were said to be high threshold and one, T, was designated low threshold. This review focuses on quantitative aspects of L-type currents. L-type channels are now distinguished according to their structure as one of four main subtypes Cav1.1 Cav1.4. L-type calcium currents play ma...
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The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy Syndrome (TS), a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted unexpected roles for the L-type voltage-gated Ca2+ channel CaV1.2 in nonexcitable cells. How abnormal Ca2+ influx through CaV1.2 underlies phenotypes such as the accompanying syndactyly or craniofacial abnormalities ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.3808